Evaluation of seminal plasma interleukin 17 in infertile males

Background: Interleukin-17 (IL-17) is a proinflammatory cytokine that involved in the pathogenesis of several autoimmune and inflammatory diseases. Inflammation testis male-reproductive tracts may lead to male infertility.Objective: To assess seminal plasma IL-17 infertile patients evaluate its relation different parameters.Patients Methods: Fifty with primary infertility were included addition 20 age-matched healthy fertile males as controls. The semen was analyzed half an hour after ejaculation according WHO criteria, including sperm count, morphology, motility, viability, leukocytecount. Seminal levels measured using ELISA technique.Results: mean level significantly higher (2.42±2.43ng/l) than controls (0.28±0.66ng/l). Also, abnormal progressive motility (4.0±2.73ng/l) normal (2.07±2.26ng/l).Conclusion: play important role associated inflammation infection genital it could be good therapeutic target those cases, but further studies are needed determine exact pathogenic infertility.